COX7A2L antibody

Catalog No. ABIN7251787

Product Details anti-COX7A2L Antibody

Target: COX7A2L (Cytochrome C Oxidase Subunit VIIa Polypeptide 2 Like (COX7A2L))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COX7A2L antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Full length fusion protein

Isotype: IgG

Application Details

Application Notes: IHC 1:30-1:150, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 2.5 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for COX7A2L

Target: COX7A2L (Cytochrome C Oxidase Subunit VIIa Polypeptide 2 Like (COX7A2L))

Alternative Name: COX7A2L (COX7A2L Products)

Synonyms: COX7AR antibody, COX7RP antibody, EB1 antibody, SIG81 antibody, SIG-81 antibody, Silg81 antibody, cytochrome c oxidase subunit 7A2 like antibody, cytochrome c oxidase subunit VIIa polypeptide 2-like antibody, COX7A2L antibody, Cox7a2l antibody

Background: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene.

UniProt: O14548