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ATM antibody

ATM Reactivity: Human, Mouse, Rat IHC (p) Host: Mouse Monoclonal 1D1 unconjugated
Catalog No. ABIN7250656
  • Target See all ATM Antibodies
    ATM (Ataxia Telangiectasia Mutated (ATM))
    Reactivity
    • 152
    • 65
    • 30
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 125
    • 21
    • 5
    • 2
    Mouse
    Clonality
    • 121
    • 32
    Monoclonal
    Conjugate
    • 77
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    This ATM antibody is un-conjugated
    Application
    • 68
    • 50
    • 39
    • 34
    • 28
    • 23
    • 23
    • 20
    • 19
    • 12
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Characteristics
    Monoclonal Antibody
    Purification
    Protein A purification
    Immunogen
    Recombinant Protein of ATM of ATM
    Clone
    1D1
    Isotype
    IgG
    Top Product
    Discover our top product ATM Primary Antibody
  • Application Notes
    IHC 1:100-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    ATM (Ataxia Telangiectasia Mutated (ATM))
    Alternative Name
    ATM (ATM Products)
    Background
    The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
    UniProt
    Q13315
    Pathways
    p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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