MGC76180 antibody, MGC80733 antibody, 4931430I01Rik antibody, AI452351 antibody, PP3051 antibody, mitocalcin antibody, MST133 antibody, MSTP133 antibody, SWS2 antibody, RGD1559565 antibody, EF-hand domain family member D1 antibody, EF-hand domain family member D1 L homeolog antibody, EF-hand domain family, member D1 antibody, EF hand domain containing 1 antibody, efhd1 antibody, EFHD1 antibody, efhd1.L antibody, Efhd1 antibody
Background
This gene encodes a member of the EF-hand super family of calcium binding proteins, which are involved in a variety of cellular processes including mitosis, synaptic transmission, and cytoskeletal rearrangement. The protein encoded by this gene is composed of an N-terminal disordered region, proline-rich elements, two EF-hands, and a C-terminal coiled-coil domain. This protein has been shown to associate with the mitochondrial inner membrane, and in HeLa cells, acts as a novel mitochondrial calcium ion sensor for mitochondrial flash activation. Alternative splicing results in multiple transcript variants.EFHD1 (EF-Hand Domain Family Member D1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is EFHD2.