DOK3 antibody
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- Target See all DOK3 Antibodies
- DOK3 (Docking Protein 3 (DOK3))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DOK3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Characteristics
- Polyclonal Antibody
- Purification
- Antigen affinity purification
- Immunogen
- Fusion protein of human DOK3
- Isotype
- IgG
- Top Product
- Discover our top product DOK3 Primary Antibody
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- Application Notes
- WB 1:500-1:2000, ELISA 1:1000-1:5000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.4 mg/mL
- Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- DOK3 (Docking Protein 3 (DOK3))
- Alternative Name
- DOK3 (DOK3 Products)
- Synonyms
- DOK3 antibody, DOKL antibody, AI450713 antibody, Dokl antibody, docking protein 3 antibody, DOK3 antibody, Dok3 antibody
- Background
- DOK3 gene maps to chromosome 5q35.3. Dok3 was tyrosine phosphorylated by Src family members Lck, Fyn, and Lyn. Immunoprecipitation studies showed that Dok3 bound inhibitors SHIP and Csk but did not bind RasGAP. Dok3 binding to SHIP occurred via the SH2 domain. Dok3 also bound Csk via the Csk SH2 domain with possible involvement of the Csk SH3 domain as well.DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function
- Molecular Weight
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Observed_MW: Refer to figures
Calculated_MW: 53 kDa
- UniProt
- Q7L591
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