CORO2B antibody

Catalog No. ABIN7248476

Product Details anti-CORO2B Antibody

Target: CORO2B (Coronin, Actin Binding Protein, 2B (CORO2B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CORO2B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human CORO2B

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:5000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.5 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CORO2B

Target: CORO2B (Coronin, Actin Binding Protein, 2B (CORO2B))

Alternative Name: CORO2B (CORO2B Products)

Synonyms: CLIPINC antibody, E130012P22Rik antibody, CORO2B antibody, coro2b antibody, Coronin-2B antibody, coronin 2B antibody, coronin, actin binding protein, 2B antibody, coronin, actin binding protein, 2Ba antibody, coronin-2B antibody, coronin, actin binding protein, 2B L homeolog antibody, CORO2B antibody, Coro2b antibody, coro2b antibody, coro2ba antibody, LOC100342263 antibody, coro2b.L antibody

Background: Coronins are a family of WD repeat-containing, actin-binding proteins that localize to submembraneous areas and regulate cell motility and cytoskeletal rearrangement. Coronin 1A (CORO1A, CLIPINA, CLABP, TACO, p57) can form coiled coil-mediated homotrimeric complexes that influence early phagosome formation. PKC-dependent phosphorylation of Coronin 1B (CORO1B) at Serine 2 regulates leading edge dynamics and cell motility in fibroblasts through interactions with Arp2/3 complex. Coronin 1C (CORO1C, Coronin 3, HCRNN4) is abundant in differentiating Neuro-2a cells, PC-12 cells and primary oligodendrocytes, where it is thought to influence neuron morphogenesis and migration. Coronin 2A (CORO2A, CLIPINB, IR10, WDR2) is a component of the approximately 1.5-2 megadalton N-CoR (nuclear receptor corepressor) complex of 10-12 proteins, which recruits HDACs to generate repressive chromatin. Coronin 7 (CORO7, CRN7) localizes to the Golgi membrane and influences the organization of intracellular membrane compartments and vesicular trafficking. Coronin 2B (CORO2B, CLIPINC) and Coronin 6 (CORO6) are similar to other members of this family, since they possess a conserved basic N-terminal motif and 3-10 WD repeats clustered in one to two core domains.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 55 kDa

UniProt: Q9UQ03