MORF4L2 antibody

Catalog No. ABIN7248473

Product Details anti-MORF4L2 Antibody

Target: MORF4L2 (Mortality Factor 4 Like 2 (MORF4L2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MORF4L2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human MORF4L2

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.7 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MORF4L2

Target: MORF4L2 (Mortality Factor 4 Like 2 (MORF4L2))

Alternative Name: MORF4L2 (MORF4L2 Products)

Synonyms: morf4l2 antibody, MORF4L2 antibody, DKFZp468A0820 antibody, MORFL2 antibody, MRGX antibody, 2410017O14Rik antibody, Mrgx antibody, Sid393p antibody, mKIAA0026 antibody, LRRG00119 antibody, mortality factor 4 like 1 antibody, mortality factor 4 like 2 antibody, morf4l1 antibody, MORF4L2 antibody, Morf4l2 antibody

Background: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 32 kDa

UniProt: Q15014

Pathways: Regulation of Muscle Cell Differentiation