WRNIP1 antibody

Catalog No. ABIN7004728

Product Details anti-WRNIP1 Antibody

Target: WRNIP1 (Werner Helicase Interacting Protein 1 (WRNIP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WRNIP1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human WRNIP1

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:100, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.96 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for WRNIP1

Target: WRNIP1 (Werner Helicase Interacting Protein 1 (WRNIP1))

Alternative Name: WRNIP1 (WRNIP1 Products)

Synonyms: WRNIP1 antibody, wrnip1 antibody, RP11-420G6.2 antibody, WHIP antibody, bA420G6.2 antibody, zgc:85976 antibody, 4833444L21Rik antibody, Wrnip antibody, Whip antibody, Werner helicase interacting protein 1 antibody, Werner helicase interacting protein 1 L homeolog antibody, ATPase WRNIP1 antibody, WRNIP1 antibody, wrnip1.L antibody, wrnip1 antibody, EDI_075920 antibody, CpipJ_CPIJ017857 antibody, PITG_07216 antibody, VDBG_02914 antibody, Wrnip1 antibody, PGTG_08805 antibody

Background: Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.

UniProt: Q96S55