FGFR4 antibody

Catalog No. ABIN7248038

Product Details anti-FGFR4 Antibody

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGFR4 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human FGFR4

Isotype: IgG

Application Details

Application Notes: IHC 1:10-1:50, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.72 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FGFR4

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Alternative Name: FGFR4 (FGFR4 Products)

Synonyms: FGFR4 antibody, XFGFR-4 antibody, XFGFR-4a antibody, cd334 antibody, fgfr-4 antibody, jtk2 antibody, tkf antibody, xfgfr4 antibody, CD334 antibody, JTK2 antibody, TKF antibody, Fgfr-4 antibody, etID309818.21 antibody, wu:fc13h10 antibody, zgc:111935 antibody, fgfr-4c antibody, fgfr4 antibody, fibroblast growth factor receptor 4 antibody, fibroblast growth factor receptor 4 S homeolog antibody, FGFR4 antibody, fgfr4 antibody, Fgfr4 antibody, fgfr4.S antibody

Background: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. FGFR4 (Fibroblast Growth Factor Receptor 4) is a Protein Coding gene. Diseases associated with FGFR4 include Prostate Cancer and Neuroma. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGFR3.

UniProt: P22455

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding