CKMT1 antibody

Catalog No. ABIN7247918

Product Details anti-CKMT1 Antibody

Target: CKMT1 (Creatine Kinase, Mitochondrial 1, Ubiquitous (CKMT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CKMT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human CKMT1A/CKMT1B

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.68 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CKMT1

Target: CKMT1 (Creatine Kinase, Mitochondrial 1, Ubiquitous (CKMT1))

Alternative Name: CKMT1A/CKMT1B (CKMT1 Products)

Synonyms: fb37h03 antibody, fb69a12 antibody, wu:fb37h03 antibody, wu:fb69a12 antibody, Mt-CK antibody, ScCKmit antibody, UbCKmit antibody, mi-CK antibody, Ckmt1 antibody, creatine kinase, mitochondrial 1 antibody, creatine kinase, mitochondrial 1, ubiquitous antibody, ckmt1 antibody, Ckmt1 antibody

Background: Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80 % homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 47 kDa

UniProt: P12532