1190009B22 antibody, Jr2 antibody, [s]3A antibody, zgc:101676 antibody, zgc:112172 antibody, ap1s3 antibody, adaptor-related protein complex AP-1, sigma 3 antibody, adaptor related protein complex 1 sigma 3 subunit antibody, adaptor-related protein complex 1, sigma 3 subunit, b antibody, adaptor-related protein complex 1, sigma 3 subunit, a antibody, adaptor related protein complex 1 sigma 3 subunit S homeolog antibody, Ap1s3 antibody, AP1S3 antibody, ap1s3b antibody, ap1s3a antibody, ap1s3.S antibody
Background
This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants.