ARIH2 antibody

Catalog No. ABIN7247255

Product Details anti-ARIH2 Antibody

Target: ARIH2 (protein ariadne-2 homolog (ARIH2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARIH2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human ARIH2

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:5000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.38 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ARIH2

Target: ARIH2 (protein ariadne-2 homolog (ARIH2))

Alternative Name: ARIH2 (ARIH2 Products)

Synonyms: ARI2 antibody, TRIAD1 antibody, AI843547 antibody, UIP48 antibody, wu:fa09c12 antibody, zgc:64093 antibody, ariadne RBR E3 ubiquitin protein ligase 2 antibody, ariadne RBR E3 ubiquitin protein ligase 2 L homeolog antibody, ariadne homolog 2 (Drosophila) antibody, ARIH2 antibody, Arih2 antibody, arih2.L antibody, arih2 antibody

Background: TRIAD1, also known as ARIH2 (ariadne homolog 2) or ARI2, is a 493 amino acid protein that contains one IBR-type zinc finger and two RING-type zinc fingers and belongs to the ariadne subfamily of RBR proteins. Localized to the nucleus, TRIAD1 interacts with UBE2L3 and is thought to act as an E3 ubiquitin-protein ligase, functioning to accept ubiquitin from E2 ubiquitin-conjugating enzymes and transfer the acquired ubiquitin residue to target substrates. TRIAD1 is subject to post-translational DNA damage-dependent phosphorylation, probably by ATM or ATR. The gene encoding TRIAD1 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 58 kDa

UniProt: O95376