RNF111 antibody

Catalog No. ABIN7246457

Product Details anti-RNF111 Antibody

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF111 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human RNF111

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:300, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.84 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RNF111

Target: RNF111 (Ring Finger Protein 111 (RNF111))

Alternative Name: RNF111 (RNF111 Products)

Synonyms: ARK antibody, Arkadia antibody, RNF111 antibody, rnf111 antibody, ark antibody, MGC81253 antibody, MGC146379 antibody, ring finger protein 111 antibody, ring finger 111 antibody, RNF111 antibody, Rnf111 antibody, rnf111-b antibody, rnf111 antibody

Background: The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

UniProt: Q6ZNA4