C8orf4 antibody

Catalog No. ABIN7246439

Product Details anti-C8orf4 Antibody

Target: C8orf4 (Chromosome 8 Open Reading Frame 4 (C8orf4))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C8orf4 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human C8orf4

Isotype: IgG

Application Details

Application Notes: IHC 1:40-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.96 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for C8orf4

Target: C8orf4 (Chromosome 8 Open Reading Frame 4 (C8orf4))

Alternative Name: C8orf4 (C8orf4 Products)

Synonyms: TC-1 antibody, TC1 antibody, 1110065B09Rik antibody, AW121743 antibody, AW321058 antibody, C8ORF4 antibody, transcriptional and immune response regulator antibody, chromosome 22 open reading frame, human C8orf4 antibody, TCIM antibody, C22H8ORF4 antibody, Tcim antibody

Background: This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.

UniProt: Q9NR00