MGP antibody

Catalog No. ABIN7246430

Product Details anti-MGP Antibody

Target: MGP (Matrix Gla Protein (MGP))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MGP antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human MGP

Isotype: IgG

Application Details

Application Notes: IHC 1:70-1:350, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.32 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MGP

Target: MGP (Matrix Gla Protein (MGP))

Alternative Name: MGP (MGP Products)

Synonyms: MGLAP antibody, NTI antibody, Mglap antibody, mgp-A antibody, MGP antibody, LOC100136434 antibody, mgp antibody, matrix Gla protein antibody, matrix Gla protein L homeolog antibody, MGP antibody, Mgp antibody, mgp.L antibody, mgp antibody

Background: Matrix Gla protein (MGP) is is a vitamin K-dependent,extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP),which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS),which is an autosomal recessive disorder characterized by abnormal cartilage calcification,peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.

UniProt: P08493