TIMM8A/DDP antibody

Catalog No. ABIN7246412

Product Details anti-TIMM8A/DDP Antibody

Target: TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMM8A/DDP antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human TIMM8A

Isotype: IgG

Application Details

Application Notes: IHC 1:40-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.84 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TIMM8A/DDP

Target: TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))

Alternative Name: TIMM8A (TIMM8A Products)

Synonyms: TIMM8A antibody, ddp antibody, tim8a antibody, timm8a antibody, DDP antibody, DDP1 antibody, DFN1 antibody, MTS antibody, TIM8 antibody, im:6896085 antibody, zgc:100916 antibody, Ddp1 antibody, Timm8a antibody, DXHXS1274E antibody, Fci-12 antibody, Tim8a antibody, translocase of inner mitochondrial membrane 8 homolog A (yeast) antibody, translocase of inner mitochondrial membrane 8A antibody, translocase of inner mitochondrial membrane 8 homolog A1 (yeast) antibody, translocase of inner mitochondrial membrane 8A1 antibody, TIMM8A antibody, timm8a antibody, Timm8a1 antibody

Background: This translocase is involved in the import and insertion of hydrophobic membrane proteins from the cytoplasm into the mitochondrial inner membrane. The gene is mutated in Mohr-Tranebjaerg syndrome/Deafness Dystonia Syndrome (MTS/DDS) and it is postulated that MTS/DDS is a mitochondrial disease caused by a defective mitochondrial protein import system. Defects in this gene also cause Jensen syndrome, an X-linked disease with opticoacoustic nerve atrophy and muscle weakness. This protein, along with TIMM13, forms a 70 kDa heterohexamer. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

UniProt: O60220