CALML5 antibody, CLSP antibody, F14B2.33 antibody, multicopy suppressors of snf4 deficiency in yeast 3 antibody, calmodulin like 5 antibody, calmodulin-like 5 antibody, Calcium-binding EF-hand family protein antibody, CALML5 antibody, MSS3 antibody
Background
This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.