PHF21A antibody

Catalog No. ABIN7246025

Product Details anti-PHF21A Antibody

Target: PHF21A (PHD Finger Protein 21A (PHF21A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHF21A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human PHF21A

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.6 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for PHF21A

Target: PHF21A (PHD Finger Protein 21A (PHF21A))

Alternative Name: PHF21A (PHF21A Products)

Synonyms: PHF21A antibody, im:7138823 antibody, si:dkey-23n7.9 antibody, BHC80 antibody, RGD1560612 antibody, 80kDa antibody, Bhc antibody, Bhc80 antibody, D030065N23Rik antibody, PFTF1 antibody, fj98d03 antibody, phf21a antibody, wu:fj98d03 antibody, PHD finger protein 21A antibody, PHD finger protein 21Aa antibody, PHD finger protein 21Ab antibody, PHF21A antibody, phf21aa antibody, pf21a antibody, phf21a antibody, LOC100549929 antibody, Phf21a antibody, phf21ab antibody

Background: Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. PHF21A (PHD finger protein 21A), also known as BRAF35-HDAC complex protein BHC80, is a 680 amino acid nuclear protein that contains one PHD-type zinc finger and one A.T hook DNA-binding domain, suggesting involvement in transcriptional regulation events. PHF21A is a component of the BHC complex, which is responsible for repressing transcription of neuron-specific genes in non-neuronal cells. The BHC complex acts as a chromatin modifier that deacetylates and demethylates specific sites on histones. PHF21A may act as a scaffold within the BHC complex. Predominantly expressed in brain, three isoforms of PHF21A exist as a result of alternative splicing events.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 75 kDa

UniProt: Q96BD5

Pathways: Feeding Behaviour