ZNF354A antibody

Catalog No. ABIN7245911

Product Details anti-ZNF354A Antibody

Target: ZNF354A (Zinc Finger Protein 354A (ZNF354A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNF354A antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human ZNF354A

Isotype: IgG

Application Details

Application Notes: IHC 1:30-1:150, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ZNF354A

Target: ZNF354A (Zinc Finger Protein 354A (ZNF354A))

Alternative Name: ZNF354A (ZNF354A Products)

Synonyms: EZNF antibody, HKL1 antibody, KID-1 antibody, KID1 antibody, TCF17 antibody, ZNF354A antibody, ZNF354B antibody, AW488485 antibody, Tcf17 antibody, Znf354a antibody, kid1 antibody, Kid1 antibody, Zfp354a antibody, zinc finger protein 354A antibody, ZNF354A antibody, Zfp354a antibody, LOC100468001 antibody, LOC100353759 antibody, Znf354a antibody

Background: ZNF354A, also called EZNF, KID-1 or TCF17, belongs to the Krüppel C2H2-type zinc-finger family of proteins that contain KRAB domains and act as transcriptional regulators. Expressed primarily in the adult kidney, ZNF354A is a transcriptional repressor that plays a role in late renal development and is suppressed after renal ischemia. The N-terminus of ZNF354A contains the KRAB domain which confers transcriptional repressor activity, while the C-terminus contains multiple Cys2His2-zinc fingers. ZNF354A is located in the nucleolus and is thought to specifically influence development of the proximal tubule by shutting off dispensable or inhibitory genes. Reduced ZNF354A expression prevents proper cell differentiation and may, therefore, be implicated in renal carcinoma.

UniProt: O60765

Pathways: Sensory Perception of Sound