MOBKL1A antibody

Catalog No. ABIN7245845

Product Details anti-MOBKL1A Antibody

Target: MOBKL1A (MOB1B) (MOB Kinase Activator 1B (MOB1B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MOBKL1A antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Full length fusion protein

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for MOBKL1A

Target: MOBKL1A (MOB1B) (MOB Kinase Activator 1B (MOB1B))

Alternative Name: MOB1B (MOB1B Products)

Synonyms: MATS2 antibody, MOB4A antibody, MOBKL1A antibody, 1110003E08Rik antibody, AU015450 antibody, B230364F10 antibody, Mobkl1a antibody, mobkl1a antibody, mobkl1aa antibody, wu:fj65h03 antibody, zgc:56156 antibody, zgc:77872 antibody, MOB1B antibody, mob4a antibody, mats2 antibody, C2orf6 antibody, MOB1 antibody, MOBK1B antibody, Mob4B antibody, cb512 antibody, mobkl1ab antibody, sb:cb512 antibody, zgc:111840 antibody, MOB kinase activator 1B antibody, MOB kinase activator 1Ba antibody, Mps one binder kinase activator-like 1A antibody, mps one binder kinase activator-like 1A antibody, MOB kinase activator 1B L homeolog antibody, MOB kinase activator 1Bb antibody, MOB1B antibody, Mob1b antibody, mob1ba antibody, mol1a antibody, LOC100282811 antibody, LOC100285953 antibody, mob1b antibody, mob1b.L antibody, mob1bb antibody

Background: The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene.Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 25 kDa

UniProt: Q7L9L4