ATF6B antibody

Catalog No. ABIN7245755

Product Details anti-ATF6B Antibody

Target: ATF6B (Activating Transcription Factor 6 beta (ATF6B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATF6B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human ATF6B

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ATF6B

Target: ATF6B (Activating Transcription Factor 6 beta (ATF6B))

Alternative Name: ATF6B (ATF6B Products)

Synonyms: CREBL1 antibody, CREB-RP antibody, G13 antibody, AA617266 antibody, ATF6beta antibody, Creb-rp antibody, Crebl1 antibody, activating transcription factor 6 beta antibody, cyclic AMP-dependent transcription factor ATF-6 beta antibody, ATF6B antibody, LOC745411 antibody, Atf6b antibody

Background: The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum, however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 77 kDa

UniProt: Q99941

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction