HLA-DRA antibody
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- Target See all HLA-DRA Antibodies
- HLA-DRA (HLA Class II DR alpha (HLA-DRA))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HLA-DRA antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), ELISA
- Characteristics
- Polyclonal Antibody
- Purification
- Antigen affinity purification
- Immunogen
- Synthetic peptide of human HLA-DRA
- Isotype
- IgG
- Top Product
- Discover our top product HLA-DRA Primary Antibody
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- Application Notes
- IHC 1:50-1:100, ELISA 1:5000-1:10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.9 mg/mL
- Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- HLA-DRA (HLA Class II DR alpha (HLA-DRA))
- Alternative Name
- HLA-DRA (HLA-DRA Products)
- Background
- HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
- UniProt
- P01903
- Pathways
- TCR Signaling, CXCR4-mediated Signaling Events, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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