ARIH1 antibody

Catalog No. ABIN7003436

Product Details anti-ARIH1 Antibody

Target: ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARIH1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human ARIH1

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:100, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.9 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ARIH1

Target: ARIH1 (Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (ARIH1))

Alternative Name: ARIH1 (ARIH1 Products)

Synonyms: ARIH1 antibody, ARI-1 antibody, ari antibody, ariadne antibody, hari antibody, hhari antibody, ubch7bp antibody, ARI antibody, HARI antibody, HHARI antibody, UBCH7BP antibody, AU021774 antibody, Ari antibody, Ari1 antibody, Hari antibody, Hhari antibody, Ubch7bp antibody, Uip77 antibody, wu:fa18d01 antibody, zgc:66364 antibody, ariadne RBR E3 ubiquitin protein ligase 1 antibody, ariadne RBR E3 ubiquitin protein ligase 1 L homeolog antibody, ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila) antibody, Arih1 antibody, ARIH1 antibody, arih1 antibody, arih1.L antibody

Background: ARIH1 (ariadne homolog), also known as ubiquitin conjugating enzyme E2 binding protein 1, ARI, HARI, HHARI (human homolog of Drosophila ariadne), MOP-6 (monocyte protein 6) or UBCH7BP (UBCH7 binding protein), is a 557 amino acid cytoplasmic protein. Expressed in a wide variety of tissues, ARIH1 contains two RING-type zinc fingers and one IBR (in-between RING fingers)-type domain. ARIH1 is believed to be involved in protein degradation and protein translation. ARIH1 interacts with UBCH7 and is thought to function as an E3 ubiquitin-protein ligase (or as a component of an E3 complex) that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme (UBCH7) and transfers that ubiquitin residue to substrates targeted for degradation. Specifically, ARIH1 interacts with and polyubiquitylates eIF4E2, thereby targeting it for proteasomal degradation.

UniProt: Q9Y4X5