C16orf45 antibody, chromosome 16 open reading frame 45 antibody, RIKEN cDNA 2900011O08 gene antibody, similar to RIKEN cDNA 2900011O08 antibody, chromosome 16 open reading frame, human C16orf45 antibody, chromosome 25 open reading frame, human C16orf45 antibody, C16orf45 antibody, 2900011O08Rik antibody, RGD1305733 antibody, C16H16orf45 antibody, C25H16orf45 antibody
Background
C16orf45, also known as FLJ32618, is a 204 amino acid protein encoded by a gene mapping to human chromosome 16. Chromosome 16 encodes over 900 genes in approximately 90 million base pairs, makes up nearly 3 % of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of Rubinstein-Taybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn's disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene. An association with systemic lupus erythematosis and a number of other autoimmune disorders with the pericentromeric region of chromosome 16 has led to the identification of SLC5A11 as a potential autoimmune modifier.