CDC123 antibody

Catalog No. ABIN7244567

Product Details anti-CDC123 Antibody

Target: CDC123 (Cell Division Cycle 123 Homolog (CDC123))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDC123 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human CDC123

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.9 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CDC123

Target: CDC123 (Cell Division Cycle 123 Homolog (CDC123))

Alternative Name: CDC123 (CDC123 Products)

Synonyms: C10orf7 antibody, D123 antibody, AA959893 antibody, G431001I09Rik antibody, c10orf7 antibody, zgc:73119 antibody, MGC82051 antibody, MGC107806 antibody, cell division cycle 123 antibody, cell division cycle 123 homolog (S. cerevisiae) antibody, cell division cycle 123 S homeolog antibody, cell division cycle protein 123 homolog antibody, CDC123 antibody, Cdc123 antibody, cdc123 antibody, cdc123.S antibody, EHI_128440 antibody, LOC725473 antibody, LOC100640991 antibody, LOC100650190 antibody

Background: The eukaryotic cell division cycle consists of a number of gene-controlled sequences that involve cyclin dependent kinases (Cdks) and cell division control (Cdc) proteins. Cdc123 (Cell division cycle protein 123), also known as D123, is a 336 amino acid cytoplasmic protein that is involved in cell cycle control. Widely expressed with high expression in thymus, spleen, ovary, testis, small intestine and leukocytes, Cdc123 functions to destabilize Chfr (checkpoint with forkhead and ring finger domain) proteins which, when accumulated, block the G to S phase transition. Cdc123 prevents the Chfr proteins from collecting in the cell, thereby allowing the cell to enter the S phase. Due to its role in cell cycle control, Cdc123 is thought to be a basal marker for luminal breast cancers.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 39 kDa

UniProt: O75794