ARHGAP49 antibody, C5orf5 antibody, FAM13B1 antibody, KHCHP antibody, N61 antibody, 2610024E20Rik antibody, AW060714 antibody, AW546153 antibody, family with sequence similarity 13 member B antibody, family with sequence similarity 13, member B antibody, FAM13B antibody, Fam13b antibody
Background
FAM13B is a 915 amino acid protein that is encoded by a gene that maps to human chromosome 5. With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6 % of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.