EMP2 antibody

Catalog No. ABIN7243274

Product Details anti-EMP2 Antibody

Target: EMP2 (Epithelial Membrane Protein 2 (EMP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EMP2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human EMP2

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.8 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EMP2

Target: EMP2 (Epithelial Membrane Protein 2 (EMP2))

Alternative Name: EMP2 (EMP2 Products)

Synonyms: MGC52916 antibody, MGC130799 antibody, MGC69514 antibody, emp2 antibody, XMP antibody, epithelial membrane protein 2 L homeolog antibody, epithelial membrane protein 2 antibody, emp2.L antibody, emp2 antibody, EMP2 antibody, Emp2 antibody

Background: EMP-2 (epithelial membrane protein 2), also known as XMP, is a 167 amino acid multi-pass membrane protein that contains four-transmembrane domains and belongs to the GAS3/PMP22 (growth arrest-specific-3/peripheral myelin protein-22) family. Localized to lipid raft domains in the plasma membrane, EMP-2 regulates the expression of several target proteins and is necessary for blastocyst implantation in the uterine endometrium. Specifically, EMP-2 mediates blastocyst implantation by controlling the cell membrane expression of MHC and glycosylphosphatidylinositol-anchored proteins, as well as Integrins and caveolin-1. In adult tissues, EMP-2 is expressed in heart, lung, ovary and intestine, while fetal expression is highest in kidney, brain and liver. Overexpression of EMP-2 is associated with endometrial adenocarcinoma, suggesting a possible role for EMP-2 in tumorigenesis.

NCBI Accession: NP_001415

UniProt: P54851