CHRNA2 antibody

Catalog No. ABIN7243172

Product Details anti-CHRNA2 Antibody

Target: CHRNA2 (Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHRNA2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human CHRNA2

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:25-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CHRNA2

Target: CHRNA2 (Cholinergic Receptor, Nicotinic, alpha 2 (Neuronal) (CHRNA2))

Alternative Name: CHRNA2 (CHRNA2 Products)

Synonyms: CHRNA2 antibody, NACHRA2 antibody, chrna2 antibody, zgc:136717 antibody, ACHR antibody, Acra-2 antibody, Acra2 antibody, BC011490 antibody, cholinergic receptor nicotinic alpha 2 subunit antibody, cholinergic receptor, nicotinic, alpha 2a (neuronal) antibody, cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal) antibody, neuronal acetylcholine receptor subunit alpha-2 antibody, neuronal acetylcholine receptor subunit alpha-4-like antibody, CHRNA2 antibody, chrna2a antibody, Chrna2 antibody, CpipJ_CPIJ002436 antibody, LOC100370261 antibody, Tsp_10995 antibody

Background: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.

Molecular Weight: 60 kDa

NCBI Accession: NP_000733

UniProt: Q15822