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B-Cell Linker antibody

BLNK Reactivity: Human, Mouse, Rat ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7243052
  • Target See all B-Cell Linker (BLNK) Antibodies
    B-Cell Linker (BLNK)
    Reactivity
    • 107
    • 72
    • 43
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 117
    • 8
    • 1
    Rabbit
    Clonality
    • 118
    • 8
    Polyclonal
    Conjugate
    • 48
    • 7
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This B-Cell Linker antibody is un-conjugated
    Application
    • 108
    • 52
    • 34
    • 26
    • 20
    • 19
    • 17
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Synthetic peptide of human BLNK
    Isotype
    IgG
    Top Product
    Discover our top product BLNK Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.6 mg/mL
    Buffer
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    B-Cell Linker (BLNK)
    Alternative Name
    BLNK (BLNK Products)
    Synonyms
    BLNK antibody, blnk antibody, MGC147045 antibody, BASH antibody, Bca antibody, Ly-57 antibody, Ly57 antibody, Lyw-57 antibody, SLP-65 antibody, AGM4 antibody, BLNK-S antibody, LY57 antibody, SLP65 antibody, bca antibody, B-cell linker antibody, B cell linker antibody, BLNK antibody, blnk antibody, Blnk antibody
    Background
    This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia.
    Molecular Weight
    50 kDa
    NCBI Accession
    NP_001107566
    UniProt
    Q8WV28
    Pathways
    BCR Signaling
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