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GRK2 antibody
ADRBK1
Reactivity: Human, Mouse, Rat
ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-GRK2 Antibody
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Target
See all GRK2 (ADRBK1) Antibodies
GRK2 (ADRBK1)
(Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
Reactivity
All reactivities for GRK2 antibodies
Human, Mouse, Rat
Host
All hosts for GRK2 antibodies
Rabbit
Clonality
All clonalities for GRK2 antibodies
Polyclonal
Conjugate
All conjugates for GRK2 antibodies
This GRK2 antibody is un-conjugated
Application
All applications for GRK2 antibodies
ELISA, Immunohistochemistry (IHC)
Characteristics
Polyclonal Antibody
Purification
Affinity purification
Immunogen
Synthetic peptide of human ADRBK1
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
IHC 1:100-1:300
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.5 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for GRK2
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Target
GRK2 (ADRBK1)
(Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
Alternative Name
GRK2 (ADRBK1 Products )
Synonyms
Adrbk-1 antibody, Bark-1 antibody, GRK2 antibody, betaARK1 antibody, BARK1 antibody, BETA-ARK1 antibody, GRK-2 antibody, Grk2 antibody, beta-adrenergic receptor kinase 1 antibody, G protein-coupled receptor kinase 2 antibody, Tsp_00497 antibody, grk2 antibody, Grk2 antibody, GRK2 antibody
Background
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
NCBI Accession
NP_001610
UniProt
P25098
Pathways
EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Regulation of G-Protein Coupled Receptor Protein Signaling , CXCR4-mediated Signaling Events , G-protein mediated Events , Interaction of EGFR with phospholipase C-gamma , Thromboxane A2 Receptor Signaling
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