ERG antibody

Catalog No. ABIN7239971

Product Details anti-ERG Antibody

Target: ERG (ERG, ETS transcription factor (ERG))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERG antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human ERG

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ERG

Target: ERG (ERG, ETS transcription factor (ERG))

Alternative Name: ERG (ERG Products)

Synonyms: erg-3 antibody, p55 antibody, erg antibody, erg_A antibody, zgc:103429 antibody, erg_E antibody, ERG antibody, D030036I24Rik antibody, KCNH2 antibody, ERG, ETS transcription factor antibody, v-ets avian erythroblastosis virus E26 oncogene homolog L homeolog antibody, v-ets avian erythroblastosis virus E26 oncogene homolog antibody, v-ets avian erythroblastosis virus E26 oncogene homolog S homeolog antibody, ETS transcription factor antibody, potassium voltage-gated channel subfamily H member 6 antibody, ERG antibody, Erg antibody, erg.L antibody, erg antibody, erg.S antibody, KCNH6 antibody

Background: This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 54 kDa

UniProt: P11308