SLIT2 antibody

Catalog No. ABIN7239467

Product Details anti-SLIT2 Antibody

Target: SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLIT2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human SLIT2

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:25-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SLIT2

Target: SLIT2 (Slit Homolog 2 (Drosophila) (SLIT2))

Alternative Name: SLIT2 (SLIT2 Products)

Synonyms: SLIL3 antibody, Slit-2 antibody, Drad-1 antibody, E030015M03Rik antibody, E130320P19Rik antibody, Slil3 antibody, mKIAA4141 antibody, Slit antibody, slil3 antibody, slit-2 antibody, slit2-a antibody, SLIT2 antibody, slit guidance ligand 2 antibody, slit homolog 2 (Drosophila) antibody, slit guidance ligand 2 S homeolog antibody, SLIT2 antibody, Slit2 antibody, slit2 antibody, slit2.S antibody

Background: Secreted leucine-rich repeat-containing proteins 1-3 (Slit1-3) are secreted glycoproteins that influence axonal guidance and mediate normal neural development by acting as high-affinity signaling ligands for the repulsive guidance receptor, Roundabout (Robo. Within the developing central nervous system (CNS) of different vertebrate systems, Slit proteins are expressed in equivalent regions, suggesting a conserved function among vertebrate homologs. Slit is expressed in the midline of the central nervous system in both vertebrates and invertebrates, where it functions as a regulatory factor of mesodermal cell movement during gastrulation. Slit2 is a short range inhibitory guidance cue for retinal ganglion cell (RGC) axons that may mediate spatial progression of RGCs.

Molecular Weight: 170 kDa

NCBI Accession: NP_004778

UniProt: O94813

Pathways: Regulation of Actin Filament Polymerization, Regulation of Cell Size, Smooth Muscle Cell Migration