CAB39 antibody

Catalog No. ABIN7239215

Product Details anti-CAB39 Antibody

Target: CAB39 (Calcium Binding Protein 39 (CAB39))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAB39 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human CAB39

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.7 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for CAB39

Target: CAB39 (Calcium Binding Protein 39 (CAB39))

Alternative Name: CAB39 (CAB39 Products)

Synonyms: CG4083 antibody, Dmel\\CG4083 antibody, Dmo25 antibody, dMo25 antibody, l(3)00274 antibody, mo25 antibody, fc06a03 antibody, zgc:86716 antibody, wu:fc06a03 antibody, MGC78903 antibody, CAB39 antibody, MO25 antibody, AA408805 antibody, AA960512 antibody, C78372 antibody, MO25alpha antibody, CG4083 gene product from transcript CG4083-RA antibody, calcium binding protein 39 antibody, calcium binding protein 39 L homeolog antibody, Cab39 protein antibody, Mo25 antibody, cab39 antibody, cab39.L antibody, CAB39 antibody, Bm1_33380 antibody, Cab39 antibody

Background: Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).

Molecular Weight: 40 kDa

NCBI Accession: NP_057373

UniProt: Q9Y376

Pathways: AMPK Signaling