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HSD11B2 antibody
HSD11B2
Reactivity: Human
ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-HSD11B2 Antibody
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Target
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HSD11B2
(Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
Reactivity
All reactivities for HSD11B2 antibodies
Human
Host
All hosts for HSD11B2 antibodies
Rabbit
Clonality
All clonalities for HSD11B2 antibodies
Polyclonal
Conjugate
All conjugates for HSD11B2 antibodies
This HSD11B2 antibody is un-conjugated
Application
All applications for HSD11B2 antibodies
ELISA, Immunohistochemistry (IHC)
Characteristics
Polyclonal Antibody
Purification
Affinity purification
Immunogen
Synthetic peptide of human HSD11B2
Isotype
IgG
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Application Details
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Application Notes
IHC 1:50-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.6 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for HSD11B2
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Target
HSD11B2
(Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2))
Alternative Name
HSD11B2 (HSD11B2 Products )
Synonyms
MGC81883 antibody, 11-HSD2 antibody, AME antibody, AME1 antibody, HSD11K antibody, HSD2 antibody, SDR9C3 antibody, 11HSD2 antibody, HSD11B2 antibody, hydroxysteroid (11-beta) dehydrogenase 2 L homeolog antibody, hydroxysteroid 11-beta dehydrogenase 2 antibody, hsd11b2.L antibody, HSD11B2 antibody, Hsd11b2 antibody
Background
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.
NCBI Accession
NP_000187
UniProt
P80365
Pathways
Steroid Hormone Biosynthesis , Regulation of Systemic Arterial Blood Pressure by Hormones
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