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Separase antibody

ESPL1 Reactivity: Human, Mouse ELISA, IHC, WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7238939
  • Target See all Separase (ESPL1) Antibodies
    Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))
    Reactivity
    • 93
    • 9
    • 1
    Human, Mouse
    Host
    • 88
    • 5
    • 1
    Rabbit
    Clonality
    • 89
    • 5
    Polyclonal
    Conjugate
    • 30
    • 9
    • 9
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Separase antibody is un-conjugated
    Application
    • 47
    • 38
    • 26
    • 26
    • 20
    • 13
    • 12
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Synthetic peptide of human ESPL1
    Isotype
    IgG
    Top Product
    Discover our top product ESPL1 Primary Antibody
  • Application Notes
    WB 1:200-1:1000, IHC 1:25-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.5 mg/mL
    Buffer
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))
    Alternative Name
    ESPL1 (ESPL1 Products)
    Background
    Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 or STAG2 in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 by ESPL1, or separase, which initiates the final separation of sister chromatids.
    Molecular Weight
    233 kDa
    NCBI Accession
    NP_036423
    UniProt
    Q14674
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