CSMD1
Reactivity: Human
IF (cc), IF (p)
Host: Rabbit
Polyclonal
Cy3
Application Notes
IHC 1:50-1:200
Restrictions
For Research Use only
Format
Liquid
Concentration
1 mg/mL
Buffer
PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target
CSMD1
(CUB and Sushi Multiple Domains 1 (CSMD1))
Alternative Name
CSMD1
Background
CSMD1 CUB and Sushi multiple domains 1 is aproteinthat in humans is encoded by theCSMD1gene. It is a potential tumoursuppressor, the deletion of whicHuman, Mouseay result in head and neckcarcinomasbehaving more aggressively. CSMD1 is part of the complement system that defends against pathogens through either the classical pathway or the alternative pathway. Located primarily in nerve growth cones, CSMD1 blocks the classical pathway of the immune system and is thought to be involved in tumor suppression, as defects in the gene encoding CSMD1 are associated with squamous cell carcinomas.