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CHRDL2 antibody

CHRDL2 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7238816
  • Target See all CHRDL2 Antibodies
    CHRDL2 (Chordin-Like 2 (CHRDL2))
    Reactivity
    • 17
    • 16
    • 13
    • 1
    Human
    Host
    • 28
    • 1
    Rabbit
    Clonality
    • 29
    Polyclonal
    Conjugate
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CHRDL2 antibody is un-conjugated
    Application
    • 22
    • 13
    • 13
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Synthetic peptide of human CHRDL2
    Isotype
    IgG
    Top Product
    Discover our top product CHRDL2 Primary Antibody
  • Application Notes
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.3 mg/mL
    Buffer
    PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CHRDL2 (Chordin-Like 2 (CHRDL2))
    Alternative Name
    CHRDL2 (CHRDL2 Products)
    Synonyms
    BNF1 antibody, CHL2 antibody, FKSG37 antibody, 1810022C01Rik antibody, Chl2 antibody, chl antibody, si:dkey-11j5.7 antibody, si:dkey-11j5.7-like antibody, chordin like 2 antibody, chordin-like 2 antibody, CHRDL2 antibody, Chrdl2 antibody, chrdl2 antibody
    Background
    CHRDL2 (chordin-related protein 2), also known as BNF1 (breast tumor novel factor 1) or CHL2 (chordin-like 2), is a 429 amino acid protein that belongs to the chordin family of proteins. CHRDL2 contains three VWFC (von Willebrand Factor type C) domains and is predominantly expressed in uterus and moderately expressed in prostate, liver, ovary, heart and testis. Due to alternative splicing events, CHRDL2 exists as five isoforms, namely isoform I, isoform II, isoform VII, isoform VIII and isoform IX. Two of these isoforms are secreted, while the other three localize to the cytoplasm. Functioning as a BMP-binding inhibitor, CHRDL2 directly interacts with BMPs and blocks their binding to BMP receptors, thereby inhibiting BMP activity. In breast, lung and colon tumors, CHRDL2 expression is upregulated, suggesting a possible role in tumorigenesis.
    Molecular Weight
    48 kDa
    NCBI Accession
    NP_056239
    UniProt
    Q6WN34
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