GJB6 antibody

Catalog No. ABIN7000954

Product Details anti-GJB6 Antibody

Target: GJB6 (Gap Junction Protein, beta 6, 30kDa (GJB6))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GJB6 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Synthetic peptide of human GJB6

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:25-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.3 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for GJB6

Target: GJB6 (Gap Junction Protein, beta 6, 30kDa (GJB6))

Alternative Name: GJB6 (GJB6 Products)

Synonyms: connexin-26 antibody, cx26 antibody, cx30 antibody, dfna3 antibody, dfna3a antibody, dfnb1 antibody, dfnb1a antibody, ed2 antibody, edh antibody, gjb6 antibody, hed antibody, nsrd1 antibody, ppk antibody, AA958971 antibody, Cx30 antibody, D14Bwg0506e antibody, CX30 antibody, DFNA3 antibody, DFNA3B antibody, DFNB1B antibody, ECTD2 antibody, ED2 antibody, EDH antibody, HED antibody, HED2 antibody, CX31 antibody, connexin 30 antibody, gap junction protein beta 2 antibody, gap junction protein beta 6 antibody, gap junction protein, beta 6 antibody, LOC387566 antibody, gjb2 antibody, GJB6 antibody, Gjb6 antibody

Background: Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia.

Molecular Weight: 30 kDa

NCBI Accession: NP_006774

UniProt: O95452

Pathways: Sensory Perception of Sound