ALDA antibody, GSD12 antibody, aldoa antibody, cb79 antibody, sb:cb79 antibody, wu:fa28b10 antibody, wu:fb10b11 antibody, ALDOA antibody, Aldo-1 antibody, Aldo1 antibody, RNALDOG5 antibody, hm:zeh0036 antibody, zgc:77696 antibody, aldolase, fructose-bisphosphate A antibody, aldolase a, fructose-bisphosphate, a antibody, aldolase, fructose-bisphosphate A S homeolog antibody, aldolase A, fructose-bisphosphate antibody, aldolase a, fructose-bisphosphate, b antibody, ALDOA antibody, aldoaa antibody, aldoa antibody, aldoa.S antibody, Aldoa antibody, aldoab antibody
Background
The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.