EST328128 antibody, M-ABC1 antibody, MABC1 antibody, 4833412N02Rik antibody, AA409895 antibody, ABCB8 antibody, zgc:113037 antibody, ATP binding cassette subfamily B member 8 antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 8 antibody, ABCB8 antibody, Abcb8 antibody, abcb8 antibody
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined, however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes.