APLCC antibody, 1100001F07Rik antibody, 1110004F07Rik antibody, C80563 antibody, MGC86432 antibody, MGC147245 antibody, fk47c09 antibody, wu:fk47c09 antibody, zgc:194876 antibody, IHQ antibody, cytochrome c oxidase subunit 7B antibody, cytochrome c oxidase subunit VIIb antibody, cytochrome c oxidase subunit VIIb L homeolog antibody, COX7B antibody, Cox7b antibody, cox7b.L antibody, cox7b antibody
Background
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22.