SIGLEC15 antibody (AA 270-320)

Catalog No. ABIN6992284

Product Details anti-SIGLEC15 Antibody

Target: SIGLEC15 (Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15))

Binding Specificity: AA 270-320

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIGLEC15 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purification: SIGLEC15 Antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-SIGLEC15 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human SIGLEC15. The immunogen is located within amino acids 270-320 of SIGLEC15.

Isotype: IgG

Application Details

Application Notes: WB: 2 μ,g/mL.

Antibody validated: Western Blot in human, mouse and rat samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: SIGLEC15 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: SIGLEC15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for SIGLEC15

Target: SIGLEC15 (Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15))

Alternative Name: SIGLEC15 (SIGLEC15 Products)

Synonyms: RGD1565948 antibody, CD33L3 antibody, HsT1361 antibody, SIGLEC-15 antibody, Cd33l3 antibody, EG620235 antibody, SIGLEC-I antibody, sialic acid binding Ig-like lectin 15 antibody, sialic acid binding Ig like lectin 15 antibody, Siglec15 antibody, SIGLEC15 antibody

Background: SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.

Molecular Weight: Predicted: 36kD

Observed: 34-36kD kDa

Gene ID: 284266

NCBI Accession: NP_998767

UniProt: Q6ZMC9