TRIM58 antibody (C-Term)

Catalog No. ABIN6992188

Product Details anti-TRIM58 Antibody

Target: TRIM58 (Tripartite Motif Containing 58 (TRIM58))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM58 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: TRIM58 Antibody is affinity chromatography purified via peptide column.

Immunogen: TRIM58 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human TRIM58.

Isotype: IgG

Application Details

Application Notes: TRIM58 antibody can be used for Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human and mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: TRIM58 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: TRIM58 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Target Details for TRIM58

Target: TRIM58 (Tripartite Motif Containing 58 (TRIM58))

Alternative Name: TRIM58 (TRIM58 Products)

Synonyms: BIA2 antibody, Gm16 antibody, Gm1783 antibody, tripartite motif containing 58 antibody, tripartite motif-containing 58 antibody, TRIM58 antibody, Trim58 antibody

Background: TRIM58 Antibody: TRIM58 is a member of the tripartite motif-containing family of proteins that frequently possess E3 ubiquitin ligase activities (1). TRIM58 is strongly expressed in erythroid lineage cells and is further upregulated during late erythroid maturation. Recent experiments suggest that TRIM58 facilitates erythroblast enucleation by ubiquitinating the intermediate chain of the microtubule motor dynein, thereby inducing proteolytic degradation (2).

Molecular Weight: Predicted: 53 kDa

Observed: 56 kDa

Gene ID: 25893

NCBI Accession: NP_056246

UniProt: Q8NG06