S1PR2 antibody (C-Term)

Catalog No. ABIN6992153

Product Details anti-S1PR2 Antibody

Target: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Binding Specificity: AA 270-320, C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This S1PR2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: S1PR2 antibody is human, mouse and rat reactive.

Purification: S1PR2 antibody is affinity chromatography purified via peptide column.

Immunogen: S1PR2 antibody was raised against an 16 amino acid peptide near the carboxy terminus of human S1PR2. The immunogen is located within amino acids 270 - 320 of S1PR2.

Isotype: IgG

Application Details

Application Notes: S1PR2 antibody can be used for detection of S1PR2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry at 10 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: S1PR2 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: S1PR2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for S1PR2

Target: S1PR2 (Sphingosine-1-Phosphate Receptor 2 (S1PR2))

Alternative Name: S1PR2 (S1PR2 Products)

Synonyms: AGR16 antibody, EDG-5 antibody, EDG5 antibody, Gpcr13 antibody, H218 antibody, LPB2 antibody, S1P2 antibody, 1100001A16Rik antibody, Edg5 antibody, LPb2 antibody, GPCR18 antibody, snGPCR18 antibody, sphingosine-1-phosphate receptor 2 antibody, S1PR2 antibody, S1pr2 antibody

Background: The Sphingosine 1-phosphate receptor 2 (S1PR2) protein was initially identified as G-protein coupled receptor thought to be involved in development (1) and was found to mediate sphingosine 1-phosphate (SPP)-induced cell rounding and neurite retraction (2). S1PR2 and the related protein S1PR3 (also known as EDG3) are also thought to mediate the SPP-induced cell proliferation, survival, and related signaling events (3). S1PR2 has also been found to be key regulator in acute vascular inflammation and may be a novel therapeutic target for vascular disorders (4).

Molecular Weight: Predicted: 39 kDa

Observed: 50 kDa

Gene ID: 9294

NCBI Accession: NP_004221

UniProt: O95136

Pathways: Synaptic Membrane