C2CD3 antibody (AA 1490-1540)

Catalog No. ABIN6992132

Product Details anti-C2CD3 Antibody

Target: C2CD3 (C2 Calcium-Dependent Domain Containing 3 (C2CD3))

Binding Specificity: AA 1490-1540

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C2CD3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: C2CD3 antibody is human, mouse and rat reactive.

Purification: C2CD3 antibody is affinity chromatography purified via peptide column.

Immunogen: C2CD3 antibody was raised against an 18 amino acid peptide near the center of human C2CD3. The immunogen is located within amino acids 1490 - 1540 of C2CD3.

Isotype: IgG

Application Details

Application Notes: C2CD3 antibody can be used for detection of C2CD3 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: C2CD3 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: C2CD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for C2CD3

Target: C2CD3 (C2 Calcium-Dependent Domain Containing 3 (C2CD3))

Alternative Name: C2CD3 (C2CD3 Products)

Synonyms: AU020772 antibody, RGD1307366 antibody, C2 calcium dependent domain containing 3 antibody, C2 calcium-dependent domain containing 3 antibody, C2CD3 antibody, C2cd3 antibody

Background: C2CD3, a putative calcium-dependent lipid-binding protein, is an essential regulator of intracellular transduction of the Hedgehog signal (1). It is localized at the basal body of cilia, mediates calcium-dependent vesicular transport and/or recruitment of proteins and regulates cilium biogenesis by promoting the assembly of centriolar distal appendages critical for docking ciliary vesicles and recruiting other essential ciliogenic proteins (2,3). C2CD3 directly promotes centriole elongation and OFD1 acts as a negative regulator of C2CD3 (4,5).

Molecular Weight: Predicted: 216, 259 kDa

Observed: 255 kDa

Gene ID: 26005

NCBI Accession: NP_001273506

UniProt: Q4AC94