DOCK8 antibody (C-Term)

Catalog No. ABIN6992016

Product Details anti-DOCK8 Antibody

Target: DOCK8 (Dedicator of Cytokinesis 8 (DOCK8))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DOCK8 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: DOCK8 antibody is human, mouse and rat reactive. Multiple isoforms of DOCK8 are known to exist.

Purification: DOCK8 antibody is affinity chromatography purified via peptide column.

Immunogen: DOCK8 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DOCK8. The immunogen is located within the last 50 amino acids of DOCK8.

Isotype: IgG

Application Details

Application Notes: DOCK8 antibody can be used for detection of DOCK8 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: DOCK8 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: DOCK8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for DOCK8

Target: DOCK8 (Dedicator of Cytokinesis 8 (DOCK8))

Alternative Name: DOCK8 (DOCK8 Products)

Synonyms: im:7154406 antibody, si:dkey-91m11.1 antibody, MRD2 antibody, ZIR8 antibody, 1200017A24Rik antibody, 5830472H07Rik antibody, A130095G14Rik antibody, AI461977 antibody, dedicator of cytokinesis 8 antibody, dock8 antibody, DOCK8 antibody, Dock8 antibody

Background: The Dedicator of cytokinesis protein 8 (DOCK8) is a member of the DOCK180 family of guanine nucleotide exchange factors (1). DOCK8 plays an essential role in humoral immune responses and is important in the proper formation of the B cell immunological synapse (reviewed in 2). Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome (3).

Molecular Weight: Predicted: 166, 220, 231 kDa

Observed: 220, 230 kDa

Gene ID: 81704

NCBI Accession: NP_982272

UniProt: Q8NF50