ATM Interactor antibody (N-Term)

Catalog No. ABIN6991999

Product Details anti-ATM Interactor Antibody

Target: ATM Interactor (ATMIN)

Binding Specificity: AA 200-250, N-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATM Interactor antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: ATMIN antibody is human, mouse and rat reactive. At least three isoforms of ATMIN are known to exist.

Purification: ATMIN antibody is affinity chromatography purified via peptide column.

Immunogen: ATMIN antibody was raised against a 19 amino acid peptide near the amino terminus of human ATMIN. The immunogen is located within amino acids 200 - 250 of ATMIN.

Isotype: IgG

Application Details

Application Notes: ATMIN antibody can be used for detection of ATMIN by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry at 5 μ,g/mL. For Immunoflorescence start at 2.5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ATMIN Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ATMIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ATM Interactor

Target: ATM Interactor (ATMIN)

Alternative Name: ATMIN (ATMIN Products)

Synonyms: Asciz antibody, mKIAA0431 antibody, RGD1305781 antibody, ASCIZ antibody, ZNF822 antibody, ATM interactor antibody, ATM interactor L homeolog antibody, Atmin antibody, ATMIN antibody, atmin.L antibody, atmin antibody

Background: The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51 (1). ATMIN is also thought to be involved in embryonic development, as an absence of ATMIN causes late-embryonic lethality in mice with a range of organ development defects (2). It also activates the transcription DYNLL1, a light chain of the dynein motor complex and sequence-specific regulator of protein dimerization of numerous targets. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a simple dynamic feedback loop for DYNLL1 expression (3).

Molecular Weight: Predicted: 73, 79, 91 kDa

Observed: 72 kDa

Gene ID: 23300

NCBI Accession: NP_056066

UniProt: O43313