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TET1 antibody (C-Term)

TET1 Reactivity: Human, Mouse, Rat WB, ELISA, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6991985
  • Target See all TET1 Antibodies
    TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))
    Binding Specificity
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 2030-2080, C-Term
    Reactivity
    Human, Mouse, Rat
    Host
    • 13
    • 7
    • 1
    Rabbit
    Clonality
    • 12
    • 9
    Polyclonal
    Conjugate
    • 17
    • 2
    • 1
    • 1
    This TET1 antibody is un-conjugated
    Application
    • 15
    • 8
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    TET1 antibody is human, mouse and rat reactive. This antibody is predicted to not cross-react with TET2 and TET3.
    Purification
    TET1 antibody is affinity chromatography purified via peptide column.
    Immunogen
    TET1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human TET1. The immunogen is located within amino acids 2030 - 2080 of TET1.
    Isotype
    IgG
    Top Product
    Discover our top product TET1 Primary Antibody
  • Application Notes
    TET1 antibody can be used for detection of TET1 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry at 5 μ,g/mL. For Immunoflorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples, Immunocytochemistry in mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    TET1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    TET1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))
    Alternative Name
    TET1 (TET1 Products)
    Synonyms
    CXXC6 antibody, LCX antibody, bA119F7.1 antibody, 2510010B09Rik antibody, AA517754 antibody, BB001228 antibody, Cxxc6 antibody, D10Ertd17e antibody, mKIAA1676 antibody, tet methylcytosine dioxygenase 1 antibody, solute carrier family 25 member 16 antibody, TET1 antibody, Tet1 antibody, SLC25A16 antibody
    Background
    TET1, a member of the ten-eleven-translocation (TET) family of genes, was initially discovered as a fusion partner of MLL in acute myeloid leukemias containing the t(10,11)(q22,q23) (1). It is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine (2). TET1 expression is regulated during inflammation in both THP-1 and primary dendritic cells, and is a negative transcriptional regulator of IL-1beta following and inflammatory stimulus (3). Recent evidence has shown that TET1 is part of a signaling pathway that regulates breast cancer growth and metastasis (4).
    Molecular Weight
    Predicted: 235 kDa

    Observed: 240 kDa
    Gene ID
    80312
    NCBI Accession
    NP_085128
    UniProt
    Q8NFU7
    Pathways
    Stem Cell Maintenance, Warburg Effect
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