GLIPR1 antibody (AA 60-110)

Catalog No. ABIN6991949

Product Details anti-GLIPR1 Antibody

Target: GLIPR1 (GLI Pathogenesis-Related 1 (GLIPR1))

Binding Specificity: AA 60-110

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLIPR1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunofluorescence (IF)

Specificity: GLIPR1 antibody is human and mouse reactive. At least two isoforms of GLIPR1 are known to exist, this antibody will detect both isoforms. This antibody is predicted to not cross-react with other GLIPR or GLIPR-like proteins.

Purification: GLIPR1 antibody is affinity chromatography purified via peptide column.

Immunogen: GLIPR1 antibody was raised against an 18 amino acid peptide near the center of human GLIPR1. The immunogen is located within amino acids 60 - 110 of GLIPR1.

Isotype: IgG

Application Details

Application Notes: GLIPR1 antibody can be used for detection of GLIPR1 by Western blot at 1 - 2 μ,g/mL. For Immunoflorescence start at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: GLIPR1 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: GLIPR1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for GLIPR1

Target: GLIPR1 (GLI Pathogenesis-Related 1 (GLIPR1))

Alternative Name: GLIPR1 (GLIPR1 Products)

Synonyms: CRISP7 antibody, GLIPR antibody, RTVP1 antibody, 2410114O14Rik antibody, RTVP-1 antibody, mRTVP-1 antibody, GLIPR1 antibody, zgc:65887 antibody, GLI pathogenesis related 1 antibody, GLI pathogenesis-related 1 antibody, GLI pathogenesis-related 1 (glioma) antibody, GLI pathogenesis-related 1b antibody, GLIPR1 antibody, Glipr1 antibody, glipr1b antibody

Background: The glioma pathogensis-related protein 1 (GLIPR1) is similar to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family (1). GLIPR1 is a tumor suppressor whose expression is regulated by p53, its increased expression is associated with myelomocytic differentiation in macrophages, whereas decreased expression of this gene through gene methylation is associated with prostate cancer (2). The GLIPR1 gene is part of a p53 target gene cluster that includes GLIPR1L1 and GLIPR1L2, two highly homologous proteins whose expression patterns vary (3).

Molecular Weight: Predicted: 29 kDa

Observed: 29 kDa

Gene ID: 11010

NCBI Accession: NP_006842

UniProt: P48060

Pathways: Regulation of Lipid Metabolism by PPARalpha