COMMD7 antibody (AA 90-140)

Catalog No. ABIN6991926

Product Details anti-COMMD7 Antibody

Target: COMMD7 (COMM Domain Containing 7 (COMMD7))

Binding Specificity: AA 90-140

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COMMD7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunofluorescence (IF)

Specificity: COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7.

Purification: COMMD7 antibody is affinity chromatography purified via peptide column.

Immunogen: COMMD7 antibody was raised against a 19 amino acid peptide near the center of human COMMD7. The immunogen is located within amino acids 90 - 140 of COMMD7.

Isotype: IgG

Application Details

Application Notes: COMMD7 antibody can be used for detection of COMMD7 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: COMMD7 antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: COMMD7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for COMMD7

Target: COMMD7 (COMM Domain Containing 7 (COMMD7))

Alternative Name: COMMD7 (COMMD7 Products)

Synonyms: commd7 antibody, MGC75822 antibody, COMMD7 antibody, LOC100230560 antibody, C20orf92 antibody, dJ1085F17.3 antibody, 2310010I22Rik antibody, AW060956 antibody, mU3 antibody, zgc:101056 antibody, COMM domain containing 7 antibody, commd7 antibody, COMMD7 antibody, LOC100230560 antibody, Commd7 antibody

Background: COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1). It associates with the NF-kB complex and suppresses its transcriptional activity (2). COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3). COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4). COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4).

Molecular Weight: Predicted: 22 kDa

Observed: 21 kDa

Gene ID: 149951

NCBI Accession: NP_444269

UniProt: Q86VX2