ERAP2 antibody (N-Term)

Catalog No. ABIN6991900

Product Details anti-ERAP2 Antibody

Target: ERAP2 (Endoplasmic Reticulum Aminopeptidase 2 (ERAP2))

Binding Specificity: AA 110-160, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERAP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: ERAP2 antibody is human reactive. Multiple isoforms of ERAP2 are known to exist. ERAP2 antibody is predicted to not cross-react with ERAP1.

Purification: ERAP2 Antibody is affinity chromatography purified via peptide column.

Immunogen: ERAP2 antibody was raised against a 17 amino acid peptide near the amino terminus of human ERAP2. The immunogen is located within amino acids 110 - 160 of ERAP2 .

Isotype: IgG

Application Details

Application Notes: ERAP2 antibody can be used for detection of ERAP2 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: ERAP2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,4 °C

Storage Comment: ERAP2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Target Details for ERAP2

Target: ERAP2 (Endoplasmic Reticulum Aminopeptidase 2 (ERAP2))

Alternative Name: ERAP2 (ERAP2 Products)

Synonyms: L-RAP antibody, LRAP antibody, ERAP2 antibody, zgc:172163 antibody, endoplasmic reticulum aminopeptidase 2 antibody, ERAP2 antibody, erap2 antibody

Background: The endoplasmic reticulum (ER) aminopeptidase 2 (ERAP2), a member of the peptidase M1 family, like the related protein ERAP1, plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides (1,2). Like ERAP1, ERAP2 is localized to the lumen of the ER and is thought to associate with ERAP1 as a heterodimer (1). Both ERAP1 and ERAP2 have been linked to several human diseases ranging from infections to autoimmunity and cancer, and may play a role in the innate immune response (reviewed in 3).

Molecular Weight: Predicted: 106 kDa

Observed: 120kDa

Gene ID: 64167

NCBI Accession: NP_071745

UniProt: Q6P179